Min Pan

An adenylyl cyclase switch reroutes carbon from growth to virulence lipids in Mycobacterium tuberculosis

The paper shows adenylyl cyclase agonists inhibit Mtb growth by rerouting carbon to virulence lipids through ETC blockade and cAMP-driven metabolic remodeling.

Gene Regulatory Network topology governs resistance and treatment escape in glioma stem-like cells

The paper shows how gene regulatory network topology in glioma stem-like cells influences drug resistance and treatment escape, suggesting strategies to overcome resistance through combinatorial therapies.

MtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infection

This study identifies MtrA as a critical regulator of peptidoglycan cleavage in Mtb, essential for survival under acidic stress and a potential drug target.

Quantitative prediction of conditional vulnerabilities in regulatory and metabolic networks of Mycobacterium tuberculosis

This paper introduces PRIME, a model predicting environment-specific vulnerabilities in Mtb's regulatory and metabolic networks, validated through genome-wide fitness screens.

Disrupting the ArcA regulatory network increases tetracycline susceptibility of TetR Escherichia coli

This study shows that disrupting the ArcA regulatory network in TetR E. coli increases tetracycline susceptibility, suggesting a strategy to re-sensitize AMR pathogens.

Intricate genetic programs controlling dormancy in Mycobacterium tuberculosis

The paper identifies a six-state genetic program in Mycobacterium tuberculosis that enables entry into and exit from hypoxia-induced dormancy through high-resolution transcriptional time-course analysis.