Wei‐Ju Wu

An adenylyl cyclase switch reroutes carbon from growth to virulence lipids in Mycobacterium tuberculosis

The paper shows adenylyl cyclase agonists inhibit Mtb growth by rerouting carbon to virulence lipids through ETC blockade and cAMP-driven metabolic remodeling.

Monocyte-amplified transcriptional signatures of human diseases

The paper introduces monocyteMINER, a method using monocyte transcriptomes to discover disease-specific biomarkers, showing improved performance for atherosclerosis and tuberculosis.

Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution

This study shows that host oxidative stress primes Mycobacterium tuberculosis for rapid antibiotic resistance evolution by creating permissive genomic backgrounds that accelerate resistance mutations.

Heat-responsive dynamic shifts in alternative splicing of the coral Acropora cervicornis

The paper investigates heat-induced alternative splicing changes in the coral Acropora cervicornis under different thermal stress conditions and finds that 40% of genes undergo alternative splicing, with intron retention dominating responses.

Gene Regulatory Network topology governs resistance and treatment escape in glioma stem-like cells

The paper shows how gene regulatory network topology in glioma stem-like cells influences drug resistance and treatment escape, suggesting strategies to overcome resistance through combinatorial therapies.

A genome-scale atlas reveals complex interplay of transcription and translation in an archaeon

This study integrates omics data to reveal post-transcriptional regulation mechanisms in Halobacterium salinarum NRC-1, showing 54% of genes are regulated by multiple mechanisms and 7% show conditional regulation.

A single-cell based precision medicine approach using glioblastoma patient-specific models

The paper uses single-cell analysis of GBM patient samples and xenografts to identify regulatory networks driving treatment-induced tumor evolution and proposes a framework for precision medicine.

Predictive regulatory and metabolic network models for systems analysis of Clostridioides difficile

The paper develops regulatory, metabolic, and integrated models for C. difficile to understand its colonization mechanisms and interactions with the gut microbiota.

Genetic program activity delineates risk, relapse, and therapy responsiveness in Multiple Myeloma

The paper identifies 141 genetic programs in multiple myeloma that predict disease outcomes and reveal mechanisms of relapse and therapy response.

MtrA regulation of essential peptidoglycan cleavage in Mycobacterium tuberculosis during infection

This study identifies MtrA as a critical regulator of peptidoglycan cleavage in Mtb, essential for survival under acidic stress and a potential drug target.