Elena B. Tikhonova

Initiation codon context governs translation-coupled mRNA decay and coordinated expression in the human parasite Leishmania

This study shows that the Kozak sequence context influences mRNA stability and protein expression in Leishmania by modulating translation-coupled decay and polysome recruitment.

Human SRP Subunits Coordinate Protein Targeting and mRNA Quality Control

This study investigates the roles of individual SRP subunits in mRNA protection and protein targeting, revealing distinct functions of S- and Alu-domain subunits in human SRP.

Loss of MAGEL2 Disrupts Pituitary Translation in a Mouse Model of PWS and Schaaf-Yang Syndrome

This study investigates the impact of Magel2 loss on pituitary translation in a mouse model of PWS and SYS, revealing translatomic alterations and their functional implications.

Molecular phenotypes segregate missense mutations in SLC13A5 Epilepsy

The paper classifies molecular defects of six SLC13A5 mutations into two classes, revealing distinct mechanisms of impaired citrate transport and protein folding, with implications for targeted therapies.