Author

Michael Hweemoon Lee

University of California San DiegoORCID 0000-0002-3676-0306Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Manuela RaffatelluiD· 3 shared Gregory T. WalkeriD· 2 shared Hiutung ChuiD· 2 shared Karsten ZengleriD· 2 shared Marvic Carrillo TerrazasiD· 2 shared Pieter C. DorresteiniD· 2 shared Rob D. KnightiD· 2 shared Simone ZuffaiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersMicrobiology

Manuela RaffatelluORCID

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3 papers

Recent·Most cited

Pan-repository analysis reveals a drug-activating function of microbial bile acid conjugation

Vincent Charron‐Lamoureux, Patricia E. Kelly, Simone Zuffa, Abubaker Patan, Marta Sala‐Climent, Corinn Walker, Haoqi Nina Zhao, Shipei Xing, Harsha Gouda, Julius Agongo, Erin R. Reilly, Lina Sallam, Selene F. H. Shore, Subhomitra Ghoshal, Anika K Harpavat, , Pieter C. Dorrestein

The paper identifies microbial bile acid conjugation as a drug-activating function for 5-ASA, revealing its therapeutic relevance through metabolomics analysis.

bioRxiv · Mar 4, 2026 · PreprintBiochemistry

PgtE protease enables virulent Salmonella to evade C3-mediated serum and neutrophil killing

Michael Hweemoon Lee, Araceli Pérez-López, Leigh A. Knodler, Grace Nguyen, Gregory T. Walker, Judith Behnsen, Steven Silva, Jean Celli, Melissa A. Tamin, Michael H. Liang, Karine Melchior, Felix A. Argueta, Sean‐Paul Nuccio, Manuela Raffatellu

This study shows that PgtE protease in virulent Salmonella Typhimurium helps evade complement-mediated killing by cleaving C3, enabling systemic spread.

mBio · Jul 14, 2025Peer-reviewedMicrobiology

Pathogenic Bacteroides fragilis strains can emerge from gut-resident commensals

Renee E. Oles, Marvic Carrillo Terrazas, Luke R. Loomis, Maxwell J. Neal, Mousumi Paulchakrabarti, Simone Zuffa, Chia-Yun Hsu, Adriana Vasquez Ayala, Michael Hweemoon Lee, Caitlin Tribelhorn, Pedro Belda‐Ferre, MacKenzie Bryant, Jasmine Zemlin, Jocelyn Young, Parambir Singh Dulai, , Hiutung Chu

This study identifies genetic factors enabling Bacteroides fragilis to transition from commensal to pathogenic by analyzing 813 strains and their genomic diversity.

bioRxiv · Jun 19, 2024 · PreprintMicrobiology