Author

Sandra v. Hardenberg

Medizinische Hochschule HannoverORCID 0000-0002-3680-7450Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Bernd AuberiD· 2 shared A. Elsayed· 1 shared A. L. Bruel· 1 shared Adam Desrochers· 1 shared Alireza SedaghatiD· 1 shared Anja Schöner-Heinisch· 1 shared Anke Lesinski‐SchiedatiD· 1 shared Anna Wiemers· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Bernd AuberORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

XPOT Deficiency causes a human disorder through impaired tRNA nuclear export

Sandra v. Hardenberg, Indra Niehaus, Anna Wiemers, Tobias Rothoeft, K. Huang, Cassidy Petree, V. Schäffer, C. Phillipe, A. L. Bruel, Klaus Warnatz, Mina Zamani, R. Ahmadi, Alireza Sedaghat, Seiamak Bahram, Sahar Sadat Sedighzadeh, , Bernd Auber

This study identifies XPOT deficiency as a human disorder causing immune defects, hearing loss, and developmental issues through impaired tRNA nuclear export.

medRxiv · Feb 4, 2026 · PreprintGenetic & Genomic Medicine

Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB

Nadja Lucas, Sophia Weidler, Antonia Eicher, Baerbel Keller, Özlem Şatırer, Adam Desrochers, Timothy J.S. Ramnarine, Mohammad Mokhtari, Sophie Elstner, Timmy Strauß, Simon Mages, Arek Kendirli, Oana Buzoianu, Lina Igel, Tim Niehues, , Min Ae Lee‐Kirsch

This study identifies truncating RELA variants causing autoinflammation and autoimmunity by disrupting NF-κB feedback control and immune homeostasis.

bioRxiv · Nov 9, 2025 · PreprintImmunology

GenOtoScope: Towards automating ACMG classification of variants associated with congenital hearing loss

Damianos P. Melidis, Christian Landgraf, Gunnar Schmidt, Anja Schöner-Heinisch, Sandra v. Hardenberg, Anke Lesinski‐Schiedat, Wolfgang Nejdl, Bernd Auber

GenOtoScope automates ACMG/AMP variant classification for congenital hearing loss, achieving higher accuracy and precision than existing tools.

PLoS Computational Biology · Sep 21, 2022Peer-reviewedBioinformatics