Author

Tim Niehues

Helios Klinikum KrefeldORCID 0000-0002-9945-8833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Adam Desrochers· 1 shared Antonia Eicher· 1 shared Arek KendirliiD· 1 shared Baerbel KelleriD· 1 shared Catharina SchütziD· 1 shared Christine WolfiD· 1 shared Hagen Ott· 1 shared Jasmin Beate Kümmerle-Deschner· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Adam Desrochers

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1 paper

Recent·Most cited

Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB

Nadja Lucas, Sophia Weidler, Antonia Eicher, Baerbel Keller, Özlem Şatırer, Adam Desrochers, Timothy J.S. Ramnarine, Mohammad Mokhtari, Sophie Elstner, Timmy Strauß, Simon Mages, Arek Kendirli, Oana Buzoianu, Lina Igel, Tim Niehues, , Min Ae Lee‐Kirsch

This study identifies truncating RELA variants causing autoinflammation and autoimmunity by disrupting NF-κB feedback control and immune homeostasis.

bioRxiv · Nov 9, 2025 · PreprintImmunology