Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB
Nadja Lucas, Sophia Weidler, Antonia Eicher, Baerbel Keller, Özlem Şatırer, Adam Desrochers, Timothy J.S. Ramnarine, Mohammad Mokhtari, Sophie Elstner, Timmy Strauß, Simon Mages, Arek Kendirli, Oana Buzoianu, Lina Igel, Tim Niehues, , Min Ae Lee‐Kirsch
This study identifies truncating RELA variants causing autoinflammation and autoimmunity by disrupting NF-κB feedback control and immune homeostasis.
bioRxiv · Nov 9, 2025 · PreprintImmunology