UBR-1 deficiency leads to ivermectin resistance in C. elegans
Yi Li, Long Gong, Jing Wu…·Shangbang Gao
This study shows that UBR-1 deficiency in C. elegans causes ivermectin resistance by disrupting glutamate signaling and GluCl function.
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Huazhong University of Science and TechnologyORCID 0000-0002-3719-7631Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Yi Li, Long Gong, Jing Wu…·Shangbang Gao
This study shows that UBR-1 deficiency in C. elegans causes ivermectin resistance by disrupting glutamate signaling and GluCl function.
Yi Li, Jyothsna Chitturi, Bin Yu…·Shangbang Gao
The paper shows that UBR-1 regulates synaptic strength between GABAergic and glutamatergic signaling in C. elegans by suppressing inhibitory glutamate signaling in DVB neurons.
Zhongpu Yue, Yi Li, Bin Yu…·Shangbang Gao
This study identifies TWK-40, a K2P channel, as essential for regulating rhythmic motor activity in C. elegans by modulating DVB neuron function and Ca2+ oscillations.