Bin Yu

A tonically active master neuron continuously modulates mutually exclusive motor states at two timescales

This study identifies a master neuron in C. elegans that modulates forward and backward movement through tonic and phasic activity at different timescales.

The ubiquitin ligase UBR-1 regulates the synaptic strength between the GABAergic and glutamatergic signaling

The paper shows that UBR-1 regulates synaptic strength between GABAergic and glutamatergic signaling in C. elegans by suppressing inhibitory glutamate signaling in DVB neurons.

A Leak K+ Channel TWK-40 Regulates Rhythmic Motor Program in C. elegans

This study identifies TWK-40, a K2P channel, as essential for regulating rhythmic motor activity in C. elegans by modulating DVB neuron function and Ca2+ oscillations.

Open syntaxin overcomes synaptic transmission defects in diverse C. elegans exocytosis mutants

This study shows that overexpressing an open form of syntaxin can rescue exocytosis defects in multiple C. elegans mutants, suggesting a general mechanism to enhance synaptic transmission.

An ALS-associated mutation in human FUS reduces neurotransmission from C. elegans motor neurons to muscles

This study shows that an ALS-associated FUS mutation disrupts synaptic vesicle docking and neuromuscular transmission in C. elegans.