Mei Zhen

The paper analyzes brain-wide neural activity in C. elegans during olfactory navigation and identifies functional circuits linking sensory input to motor behavior across different environments and behavioral states.

This study identifies a membrane potential-independent role for the K2P channel TWK-40 in regulating presynaptic organisation through intracellular potassium levels and interactions with PYK-1 and transcription factors.

The paper maps the multiscale structure of human liver tissue using electron microscopy and deep learning, revealing vascular, cellular, and organelle organization and dynamics.

The paper identifies three muscle-specific DAF-16/FOXO targets activated by reduced insulin/IGF-1 signaling in C. elegans through transcriptomic and chromatin analyses.

This study shows that UBR-1 deficiency in C. elegans causes ivermectin resistance by disrupting glutamate signaling and GluCl function.

This study identifies a master neuron in C. elegans that modulates forward and backward movement through tonic and phasic activity at different timescales.

The paper shows that UNC-8, an ENaC protein, promotes Ca2+-dependent endocytosis to dismantle and recycle presynaptic components during neuronal remodeling in C. elegans.

The paper shows that UBR-1 regulates synaptic strength between GABAergic and glutamatergic signaling in C. elegans by suppressing inhibitory glutamate signaling in DVB neurons.

mEMbrain provides an interactive MATLAB tool for connectomic segmentation, enabling user-friendly analysis of EM datasets with pre-trained networks and ground truth annotations.

The paper studies how C. elegans chemosensory neurons encode olfactory information through ensemble activity and natural stimuli.

The paper investigates how two interneurons, RIS and RIM, coordinate electrical and chemical signaling to control motor state transitions in C. elegans.

The paper shows that juvenile C. elegans generate symmetric motor patterns through an asymmetric motor circuit, with dorsal bending driven by synaptic wiring and ventral bending via extrasynaptic signaling from premotor interneurons.

This study identifies six signaling pathways regulating the proliferation and developmental potential of human neuroepithelial stem cells in vitro.

This study identifies TWK-40, a K2P channel, as essential for regulating rhythmic motor activity in C. elegans by modulating DVB neuron function and Ca2+ oscillations.

The paper identifies cholecystokinin signaling as essential for robust escape steering in C. elegans by modulating motor neuron activity during escape responses.

The paper reconstructs the post-embryonic maturation of the C. elegans motor circuit using electron microscopy, showing how structural rewiring maintains functional output during development.

The paper provides a detailed structural analysis of the anterior sensilla in C. elegans dauer larvae using FIB-SEM, revealing previously unknown neuronal structures.

The paper studies brain-wide activity in C. elegans during mating, showing how sensory context shapes diverse neural dynamics across different behavioral components.

This study uses connectomics to show how brain circuits change with age in C. elegans, revealing principles of brain maturation through structural and functional remodeling.

This study shows that corollary discharge from the motor circuit to the sensory processing circuit in C. elegans sustains motor state during thermotactic navigation.

This study shows that overexpressing an open form of syntaxin can rescue exocytosis defects in multiple C. elegans mutants, suggesting a general mechanism to enhance synaptic transmission.

This study shows that an ALS-associated FUS mutation disrupts synaptic vesicle docking and neuromuscular transmission in C. elegans.

This study identifies a gain-of-function mutation in the UNC-2/CaV2α channel in C. elegans that causes hyperactivity and excitation-dominant synaptic transmission by altering cholinergic and GABAergic transmission.

The paper identifies functional dendritic spines in C. elegans GABAergic motor neurons and describes their structural and functional characteristics.

This paper introduces a 3D co-culture model of human skeletal muscle and motor neurons to study adult neuromuscular junction development and disease, showing increased receptor upregulation and disease modeling capability.

The paper introduces an automated method to classify synaptic vesicles in C. elegans electron tomograms using machine learning, finding increased DCVs and greater distance from AZs in dauer larvae.

The paper investigates how AVB-B gap junctions in C. elegans facilitate undulatory wave propagation during forward locomotion through intrinsic motor neuron oscillations and proprioceptive coupling.

The paper shows that UBR-1 in C. elegans regulates glutamate levels, affecting motor neuron activity and locomotion.

The paper identifies class A motor neurons in C. elegans as intrinsic oscillators driving reverse locomotion without premotor interneurons.

The paper identifies a neuroendocrine neuron, RID, in C. elegans that sustains forward movement through the neuropeptide FLP-14.