Johann Mignolet

This study uses a phage endolysin to target Streptococcus salivarius in the gut, revealing niche overlap with butyrate-producing taxa and potential therapeutic benefits.

The paper identifies a conserved transporter-repressor module in streptococci that directly couples bacteriocin detection to transcriptional activation, revealing a minimalist and rapid mechanism for antimicrobial peptide resistance.

The paper develops a modular genetic toolbox for gene regulation and multi-color imaging in streptococci by benchmarking fluorescent proteins and creating versatile cassettes for different species.

This paper identifies the pneumococcal S protein as essential for resisting host antimicrobials by coordinating cell wall modification and repair through interactions with PBP1a and PgdA.

The paper shows that S. salivarius uses both peptides and organic molecules to activate its quorum sensor, revealing a new signaling mechanism in bacterial communication.

This paper identifies novel class II bacteriocins in Streptococcus salivarius using bioinformatics and synthetic biology, revealing 50 candidates active against Gram-positive pathogens.