Cancer BiologyCell Death and DiseasePeer-reviewed
RET Receptor Tyrosine Kinase Promotes Breast Cancer Metastasis to the Brain and RET Inhibitors Pralsetinib and Selpercatinib Suppress Breast Cancer Brain Metastases
Angelina T. Regua, Shivani Bindal, Mariana K. Najjar…·Hui‐Wen Lo
This study shows RET is highly activated in breast cancer brain metastases and that RET inhibitors reduce metastasis and tumor growth in preclinical models.
DOI 10.1038/s41419-026-08890-z