Author

Mariana K. Najjar

Texas A&M Health Science CenterORCID 0000-0001-6423-6854Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Hui‐Wen LoiD· 2 shared Angelina T. ReguaiD· 1 shared Ankush ChandraiD· 1 shared Antonio DonoiD· 1 shared Austin ArrigoiD· 1 shared Chuling ZhuangiD· 1 shared Dongqin ZhuiD· 1 shared Jay‐Jiguang ZhuiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Hui‐Wen LoORCID

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2 papers

Recent·Most cited

Cancer BiologyCell Death and DiseasePeer-reviewedJun 1, 2026

RET Receptor Tyrosine Kinase Promotes Breast Cancer Metastasis to the Brain and RET Inhibitors Pralsetinib and Selpercatinib Suppress Breast Cancer Brain Metastases

Angelina T. Regua, Shivani Bindal, Mariana K. Najjar…·Hui‐Wen Lo

This study shows RET is highly activated in breast cancer brain metastases and that RET inhibitors reduce metastasis and tumor growth in preclinical models.

DOI 10.1038/s41419-026-08890-z

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintFeb 20, 2025

Targeting tGLI1, a novel mediator of tumor therapeutic resistance, using Ketoconazole sensitizes glioblastoma to CDK4/6 therapy and Chemoradiation

Yu Pu Yang, Austin Arrigo, Ankush Chandra…·Hui‐Wen Lo

This paper identifies tGLI1 as a mediator of GBM resistance to CDK4/6 inhibitors and shows that ketoconazole sensitizes GBM to CDK4/6 therapy and chemoradiation.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky