DUSP6 loss enhances dopamine secretion and modulate neurodevelopment in ADHD iPSC-derived dopaminergic neurons
Atefeh Namipashaki, Shane D. Hellyer, Aurina Arnatkevičiūtė…·Ziarih Hawi
This study investigates the role of DUSP6 in ADHD by generating DUSP6 knockouts in iPSC-derived dopaminergic neurons, finding increased dopamine secretion and transcriptomic changes linked to neurodevelopment and psychiatric disorders.