Author

Shane D. Hellyer

Monash UniversityORCID 0000-0003-0688-6060Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Karen J. GregoryiD· 4 shared Atefeh NamipashakiiD· 2 shared Aurina ArnatkevičiūtėiD· 2 shared Cameron J. NowelliD· 2 shared Jose Maria PoloiD· 2 shared Kevin S. WalshiD· 2 shared Mark A. BellgroveiD· 2 shared Ziarih HawiiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersNeuroscience

Karen J. GregoryORCID

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4 papers

Recent·Most cited

NeuroscienceBiological Psychiatry Global Open SciencePeer-reviewedOct 1, 2026

DUSP6 loss enhances dopamine secretion and modulate neurodevelopment in ADHD iPSC-derived dopaminergic neurons

Atefeh Namipashaki, Shane D. Hellyer, Aurina Arnatkevičiūtė…·Ziarih Hawi

This study investigates the role of DUSP6 in ADHD by generating DUSP6 knockouts in iPSC-derived dopaminergic neurons, finding increased dopamine secretion and transcriptomic changes linked to neurodevelopment and psychiatric disorders.

DOI 10.1016/j.bpsgos.2026.100862

humanbulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintJan 30, 2026

Targeting of subcellular metabotropic glutamate receptor 5 signaling to modulate pain transmission

Jeffri S. Retamal, Shane D. Hellyer, Paulina D. Ramírez-García…·Nicholas A. Veldhuis

This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.

DOI 10.64898/2026.01.29.702703

ratmouse

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Pharmacology & ToxicologyBiochemical PharmacologyPeer-reviewedJun 5, 2025

Pharmacological characterisation of allosteric modulators at human mGlu5

Muhammad Abdur Razzak, Kevin Tran, Roisin McCague…·Karen J. Gregory

This study evaluates the pharmacological effects of mGlu5 allosteric modulators on human mGlu5, revealing species differences and implications for drug development.

3 citations

humanexperimental assay

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NeurosciencebioRxivPreprintSep 22, 2024

Transcriptome profiling of dopaminergic neurons derived from an ADHD induced pluripotent stem cell (iPSC) model

Atefeh Namipashaki, Aurina Arnatkevičiūtė, Shane D. Hellyer…·Ziarih Hawi

This study profiles transcriptomes of dopaminergic neurons from ADHD and neurotypical iPSCs, identifying DEGs overlapping with ADHD GWAS results and suggesting delayed neuronal maturation.

DOI 10.1101/2024.09.22.614376

humanbulk RNA-seq

𝕏 PostBluesky