This study investigates the role of DUSP6 in ADHD by generating DUSP6 knockouts in iPSC-derived dopaminergic neurons, finding increased dopamine secretion and transcriptomic changes linked to neurodevelopment and psychiatric disorders.

Biological Psychiatry Global Open Science · Oct 1, 2026Peer-reviewedNeuroscience

Targeting of subcellular metabotropic glutamate receptor 5 signaling to modulate pain transmission

Jeffri S. Retamal, Shane D. Hellyer, Paulina D. Ramírez-García, Rocco Latorre, Rina Pokhrel, Thomas Paul Davis, Yifei Zhu, Michael Raymond Whittaker, Jackson Albert Kos, Kelly M O'Sullivan, Nigel W. Bunnett, Wendy L. Imlach, Daniel P. Poole, Karen J. Gregory, Nicholas A. Veldhuis

This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.

bioRxiv · Jan 30, 2026 · PreprintPharmacology & Toxicology

Pharmacological characterisation of allosteric modulators at human mGlu5

Muhammad Abdur Razzak, Kevin Tran, Roisin McCague, Kathy Sengmany, Jackson Kos, Monica Langiu, Bohan Li, Shane D. Hellyer, Karen J. Gregory

This study evaluates the pharmacological effects of mGlu5 allosteric modulators on human mGlu5, revealing species differences and implications for drug development.

Biochemical Pharmacology · Jun 5, 2025Peer-reviewedPharmacology & Toxicology

Transcriptome profiling of dopaminergic neurons derived from an ADHD induced pluripotent stem cell (iPSC) model

Atefeh Namipashaki, Aurina Arnatkevičiūtė, Shane D. Hellyer, Cameron J. Nowell, Kevin S. Walsh, Jose Maria Polo, Karen J. Gregory, Mark A. Bellgrove, Ziarih Hawi

This study profiles transcriptomes of dopaminergic neurons from ADHD and neurotypical iPSCs, identifying DEGs overlapping with ADHD GWAS results and suggesting delayed neuronal maturation.

bioRxiv · Sep 22, 2024 · PreprintNeuroscience