Author

Julia Gamache

Duke UniversityORCID 0000-0002-3750-147XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 3 Assay:ATAC-seq· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Ornit Chiba‐FalekiD· 4 shared Allison E. Ashley‐KochiD· 3 shared Elliot Keats ShwabiD· 3 shared Gregory E. CrawfordiD· 3 shared Melanie E. GarrettiD· 3 shared Daniel C. GingerichiD· 2 shared Geidy E. SerranoiD· 2 shared Julio BarreraiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersNeuroscience

Ornit Chiba‐FalekORCID

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4 papers

Recent·Most cited

Single cell transcriptomics reveals enrichment of aggregation-prone alpha-synuclein isoforms across synucleinopathies

Elliot Keats Shwab, Webb Pierson, Daniel Oliveros Gingerich, Zhaohui Man, Sapir Margalit, Dean Yona, Aasaf Sivan, Julia Gamache, Geidy E. Serrano, Thomas G. Beach, Yuval Ebenstein, Roy Beck, Ornit Chiba‐Falek

The paper uses long-read and single nucleus RNA-seq to identify novel SNCA transcript isoforms and their association with Parkinson's and Lewy body dementia.

bioRxiv · Oct 13, 2025 · PreprintNeuroscience

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases

Elliot Keats Shwab, Zhaohui Man, Daniel C. Gingerich, Julia Gamache, Melanie E. Garrett, Geidy E. Serrano, Thomas G. Beach, Gregory E. Crawford, Allison E. Ashley‐Koch, Ornit Chiba‐Falek

This study compares the transcriptomic landscapes of Alzheimer's disease, Dementia with Lewy bodies, and Parkinson's disease using single-nucleus RNA sequencing to identify shared and distinct molecular features.

Alzheimer s & Dementia · May 1, 2025Peer-reviewedNeuroscience

Integrative single-nucleus multi-omics analysis prioritizes candidate cis and trans regulatory networks and their target genes in Alzheimers disease brains

Julia Gamache, Daniel C. Gingerich, Elliot Keats Shwab, Julio Barrera, Melanie E. Garrett, Cordelia Hume, Gregory E. Crawford, Allison E. Ashley‐Koch, Ornit Chiba‐Falek

This study uses single-nucleus multi-omics data to identify cis and trans regulatory networks and their target genes in Alzheimer's disease brains.

bioRxiv · May 12, 2023 · PreprintNeuroscience

Sex dependent glial-specific changes in the chromatin accessibility landscape in late-onset Alzheimer's disease brains

Julio Barrera, Lingyun Song, Alexias Safi, Young Yun, Melanie E. Garrett, Julia Gamache, Ivana Premasinghe, Daniel Sprague, Danielle Chipman, Jeffrey Li, Hèléne Fradin, Karen L. Soldano, Raluca Gordân, Allison E. Ashley‐Koch, Gregory E. Crawford, Ornit Chiba‐Falek

The paper identifies sex-dependent glial-specific chromatin accessibility changes in late-onset Alzheimer's disease brains using ATAC-seq and links them to LOAD-GWAS regions.

Molecular Neurodegeneration · Aug 24, 2021Peer-reviewedNeuroscience