Zhaohui Man

The paper develops a blood-based diagnostic biomarker for Alzheimer's disease using microglial single-cell transcriptomics and validates it in plasma omics data.

The paper uses long-read and single nucleus RNA-seq to identify novel SNCA transcript isoforms and their association with Parkinson's and Lewy body dementia.

This study compares the transcriptomic landscapes of Alzheimer's disease, Dementia with Lewy bodies, and Parkinson's disease using single-nucleus RNA sequencing to identify shared and distinct molecular features.