Author

Marc de la Roche

University of CambridgeORCID 0000-0002-3757-082XUnclaimed ORCID profile · follow to get notified of new preprints

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Marc de la Roche1 paper

Biology Disciplines

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Aditya Sridhar· 1 shared Ioanna MelaiD· 1 shared Joseph E. ChambersiD· 1 shared Laura S. ItzhakiiD· 1 shared Maria ZacharopoulouiD· 1 shared Sergio Grannum· 1 shared Siding Qin· 1 shared Zixuan Huo· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

Aditya Sridhar

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1 paper

Recent·Most cited

Programmable DNA-peptide nanostructures for multivalent regulation of intracellular signalling

Maria Zacharopoulou, Zoya Cassidy, Siding Qin, Zixuan Huo, Sergio Grannum, Aditya Sridhar, Joseph E. Chambers, Marc de la Roche, Laura S. Itzhaki, Ioanna Mela

This paper develops DNA-peptide nanostructures to multivalently inhibit TNKS, showing they effectively downregulate Wnt signaling in cancer cells despite differences in TBP copy number.

bioRxiv · Sep 9, 2026 · PreprintBiophysics