Maria Zacharopoulou

Programmable DNA-peptide nanostructures for multivalent regulation of intracellular signalling

This paper develops DNA-peptide nanostructures to multivalently inhibit TNKS, showing they effectively downregulate Wnt signaling in cancer cells despite differences in TBP copy number.

DNA aptamers to interfere with HasA, the hemophore of the heme assimilation system in Pseudomonas aeruginosa, as a potential antimicrobial strategy

This paper identifies DNA aptamers that bind the truncated form of HasA, a hemophore in Pseudomonas aeruginosa, under acidic conditions, showing potential as antimicrobial agents.

A generalisable method for the purification and biophysical characterisation of bacterial membrane receptors

This paper describes a method to purify and characterize soluble domains of bacterial membrane receptors, demonstrating its effectiveness with the HasR receptor from Pseudomonas aeruginosa.

Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilising Effects on the Scaffold PR65

The paper investigates how two small molecule activators of PP2A, ATUX-8385 and DBK-776, affect the structural stability of the PR65 scaffold using biophysical and computational methods.

A facile and reproducible method for the purification of peptide- and protein-functionalized DNA nanostructures

This paper introduces a fast and efficient purification method for peptide- and protein-functionalized DNA nanostructures with high yield and purity.

Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome

This study develops D-box peptides that inhibit APC/C by binding Cdc20, showing they are more potent than Apcin and can drive protein degradation.

Local ionic conditions modulate the aggregation propensity and influence the structural polymorphism of alpha-synuclein

This study investigates how Ca2+ and Na+ ions affect alpha-synuclein aggregation and fibril polymorphism, revealing their distinct roles in modulating conformational dynamics and structural outcomes.

Local structural dynamics of alpha-synuclein correlate with aggregation in different physiological conditions

The paper measures how different cellular environments affect alpha-synuclein's structure and aggregation, finding that specific regions drive nucleation and fibril elongation.