Kehui Xiang

PAL-AI predicts poly(A)-tail length changes in oocytes, identifies genetic variants under negative selection linked to human fertility.

This study identifies how 5' UTR features and upstream AUGs regulate translation efficiency in Toxoplasma gondii using ribosome profiling and synthetic reporter assays.

The paper shows that eIF1 release during mitosis increases start-codon selection stringency, altering translation and affecting mitotic cell survival.

The paper identifies regulatory elements that control mRNA poly(A)-tail length and translation in vertebrate oocytes and embryos, showing conservation across species.

The paper investigates how poly(A)-tail length influences translational efficiency in oocytes and embryos, showing that PABPC availability and mRNA stability mechanisms determine this coupling.