Jimmy Ly

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

The paper generates a high-resolution proteogenomic atlas of human neuronal development using long-read RNA sequencing and proteomics, revealing novel isoforms and their role in neurodevelopmental risk mechanisms.

5' UTR length regulates alternative N-terminal protein isoform production in health and disease

This study shows that 5' UTR length influences alternative N-terminal protein isoform production through start codon selection and demonstrates this in health and disease.

SRSF12 is a primate-specific splicing factor that induces a tissue-specific gene expression program

This study identifies SRSF12 as a primate-specific splicing factor that induces tissue-specific gene expression programs in human cells.

Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells

The paper shows that during prolonged mitotic arrest, the transcriptome is stabilized through increased mRNA half-lives and reduced deadenylation, dependent on PABPC1 and PABPC4.

Alternative start codon selection shapes mitochondrial function during evolution, homeostasis, and disease

The paper identifies differentially-localized protein isoforms generated by alternative start codon selection and shows their role in mitochondrial function, evolution, and disease.

Molecular determinants of RNase MRP specificity and function

The paper identifies C18orf21/RMRPP1 as an RNase MRP-specific protein, reveals its role in 40S ribosome biogenesis, and identifies Nepro as an essential rRNA processing factor.

Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing

This study identifies a DNA binding region in MORC2 that is essential for gene silencing and shows that phosphorylation affects its DNA affinity and nuclear localization.

Nuclear release of eIF1 globally increases stringency of start-codon selection to preserve mitotic arrest physiology

The paper shows that eIF1 release during mitosis increases start-codon selection stringency, altering translation and affecting mitotic cell survival.

A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo development

This study identifies a germline-specific DSN1 splice isoform essential for oocyte maturation and early embryonic development in mammals.

Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos

The paper identifies regulatory elements that control mRNA poly(A)-tail length and translation in vertebrate oocytes and embryos, showing conservation across species.

CanDIG: Secure Federated Genomic Queries and Analyses Across Jurisdictions

CanDIG enables secure, federated genomic and health data analysis across jurisdictions while maintaining data locality and privacy.

The RNA-binding protein, Rasputin/G3BP, enhances the stability and translation of its target mRNAs

This study identifies RIN/G3BP-bound mRNAs in Drosophila and shows they are short, stable, and highly translated, suggesting RIN stabilizes and enhances their translation.