Kuan-Chung Su

Functional genetics reveals a role for the proteasome in regulating centromere assembly

The paper identifies the proteasome's role in regulating CENP-T levels to prevent non-centromere kinetochore assembly.

Systematic functional genetic analysis of cell-substrate adhesion

This study identifies gene targets involved in cell-substrate adhesion through functional genetic analyses in human cells, revealing dynamic requirements and novel regulators.

The dynamics of centromere assembly and disassembly during quiescence

The paper examines centromere protein dynamics during quiescence entry and exit, showing rapid disassembly and reassembly of centromere proteins with specific timing for CENP-A deposition.

Functional genetics with a hypomorphic CENP-C mutant reveals a regulatory system for chromosome congression

The paper identifies KIF18A as a gene whose knockout causes synthetic lethality with a hypomorphic CENP-C mutant, revealing a regulatory system for chromosome congression.

Differential roles for the spindle assembly checkpoint in error surveillance and mitotic timing

This study investigates the role of the SAC in mitotic timing and error surveillance, finding that Mad2 is dispensable for viability in Cdc20 {Delta}FL cells and that mitotic timing depends on multiple interdependent pathways.

Nuclear release of eIF1 globally increases stringency of start-codon selection to preserve mitotic arrest physiology

The paper shows that eIF1 release during mitosis increases start-codon selection stringency, altering translation and affecting mitotic cell survival.

Functional genetics reveals modulators of anti-microtubule drug sensitivity

The paper identifies gene targets that modulate sensitivity to anti-microtubule drugs using CRISPR screens in human cells.