Berenice Furlan

Phosphate-responsive ornithine lipid biosynthesis remodels outer membrane composition and contributes to polymyxin tolerance

This study identifies OlsF-dependent ornithine lipid biosynthesis as a phosphate-responsive pathway that remodels the outer membrane and enhances polymyxin tolerance in Enterobacterales.

PBP1A and LdtJ support cell envelope homeostasis and impact selection of Colistin-resistance in Acinetobacter baumannii

This study identifies the functional interplay between PBP1A and LdtJ in Acinetobacter baumannii, showing that disrupting their coordination weakens the cell envelope and increases colistin resistance.

Outer membrane remodeling via lipid-peptidoglycan crosstalk enables lipooligosaccharide-deficient colistin resistance

The paper shows that disrupting phospholipid homeostasis in Gram-negative bacteria enables LOS-deficient, colistin-resistant variants by altering outer membrane structure and peptidoglycan synthesis.

Environmental context reveals a conditional role of the Tol-Pal system in envelope organization in Acinetobacter baumannii

This study shows that the Tol-Pal system in Acinetobacter baumannii is conditionally required for envelope organization under specific environmental stresses but not under standard lab conditions.

Peptidoglycan DD-peptidases have distinct activities that impact fitness of Acinetobacter baumannii

This study investigates the distinct roles of DD-peptidases in Acinetobacter baumannii, showing their unique contributions to cell morphology, growth, and peptidoglycan composition, with implications for antimicrobial therapy.