Rab2 and Arl8/BORC control retrograde axonal transport of dense core vesicles via Syd/dJIP3/4 and RUFY dynein adaptors
Viktor K. Lund, Antony Chirco, Michela Caliari, Andreas Haahr Larsen, Kristoffer Tollestrup Tang, Ulrik Gether, Kenneth Lindegaard Madsen, Michael Wierer, Ole Kjærulff
The paper identifies Rab2, Syd/dJIP3/4, and RUFY as key regulators of retrograde axonal transport of dense core vesicles in Drosophila, showing distinct roles in DCV motility and sorting.
The Journal of Cell Biology · Dec 10, 2025Peer-reviewedNeuroscience