Michael Wierer

MODY mutations in transcription factors HNF1A and HNF1B affect the production of interferon signaling proteins: evidence at the proteome level

The paper examines proteomic changes caused by MODY mutations in HNF1A and HNF1B using cell line models, finding suppressed energy metabolism and interferon signaling.

A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL

This study identifies histidine depletion as an antileukemic strategy in T-ALL by revealing its role in suppressing cholesterol biosynthesis through ribosome stalling and GCN2 activation.

Rab2 and Arl8/BORC control retrograde axonal transport of dense core vesicles via Syd/dJIP3/4 and RUFY dynein adaptors

The paper identifies Rab2, Syd/dJIP3/4, and RUFY as key regulators of retrograde axonal transport of dense core vesicles in Drosophila, showing distinct roles in DCV motility and sorting.

New methods on the block: Taxonomic identification of archaeological bones in resin-embedded sediments through palaeoproteomics

This paper demonstrates the successful retrieval of palaeoproteomic data from bone fragments in resin-impregnated sediment blocks, enabling microstratigraphic taxonomic identification of Pleistocene faunal remains.

The novel coronary artery disease risk factor ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1

This study identifies ADAMTS-7 as a risk factor for atherosclerosis by degrading TIMP-1, reducing its inhibition of MMP-9 and promoting collagen degradation.

FK506-binding protein 2 participates in proinsulin folding

This study identifies FKBP2 as a proline isomerase involved in proinsulin folding, showing its role in preventing misfolding and apoptosis in β-cells.

Unscheduled DNA replication in G1 causes genome instability through head-to-tail replication fork collisions

The paper induces unscheduled DNA replication in G1-phase budding yeast, showing it leads to genome instability through head-to-tail replication fork collisions during subsequent S-phase.

Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms

The paper identifies two DOMINO isoforms in Drosophila that form distinct complexes with different functions: DOM-B acts like SWR1 by depositing H2A.V, while DOM-A acts like NuA4 by acetylating H4K12.

Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive demethylation in mammals

The paper identifies DPPA3 as a driver of genome-wide passive DNA demethylation in mammals, showing it can bypass TET protein requirements and function across species.