Regulatory mechanism of heme-regulated inhibitor through autophosphorylation-driven activation and heme-induced deactivation
Tomomasa Oka, Hisashi Yoshida, K. Mizutani…·Kenji Iwasaki
This study identifies autophosphorylation-driven activation and heme-induced deactivation mechanisms of HRI, revealing how phosphorylation and heme regulate its interaction with eIF2.