NeurosciencebioRxivPreprint
Enhanced mTORC1 signaling and Protein Synthesis in Parkinson Disease Pathogenesis
Mohammed Repon Khan, Xiling Yin, Sung-Ung Kang…·Ted M. Dawson
This study identifies that pathological α-synuclein destabilizes the TSC1-TSC2 complex, activates mTORC1, and enhances protein translation, contributing to neurodegeneration in Parkinson's disease.
DOI 10.1101/2022.10.03.510455