John C. Newman

Ketone ester supplementation reduces age-associated B cell activation in aged mice without impairing antibody responses

Advanced Open-Source Experimental-Design Tools for Microplate-Based Assays with Acoustic Liquid Handling

The paper introduces PickliPy, an open-source framework for converting assay designs into ADE picklists, enabling reproducible and scalable microplate-based experiments.

Requirement for oxidation of neuronal ketone bodies in aging andneurodegeneration

This study shows ketone body oxidation is essential for neuronal function and survival, particularly in neurodegenerative diseases like Alzheimer's.

Ketone body beta-hydroxybutyrate restores neuronal Tau proteostasis via ketolysis-independent mechanism

This study shows that beta-hydroxybutyrate (betaHB) improves neuronal Tau proteostasis and reduces Tau aggregation in tauopathy models, independent of its ketolysis for ATP production.

Ketone bodies mitigate against systemic inflammation-induced changes in brain energy metabolism and delirium-like deficits in aged mice

This study shows that ketone bodies reduce brain energy metabolism disruption and prevent delirium-like cognitive deficits in aged mice during systemic inflammation.

Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan.

Gly-Low compounds reduce glycation, lower food intake, improve insulin sensitivity, and extend lifespan in mice by inhibiting ghrelin signaling and enhancing mTOR pathways.

Ketogenic diet administration later in life improves memory and regulates the synaptic cortical proteome through the cAMP/PKA signaling pathway in aging mice.

This study shows that a short-term cyclic ketogenic diet improves memory and synaptic plasticity in aged mice by modulating the cAMP/PKA signaling pathway and cytoskeleton dynamics.

Small-molecule ketone esters treat brain network abnormalities in an Alzheimer's disease mouse model

The paper shows that small-molecule ketone esters reduce epileptiform discharges and improve cognition in an Alzheimer's disease mouse model.