Sandra B. Lemke

This study identifies Tono as a mechanically responsive transcriptional regulator that controls sarcomere maturation through liquid-liquid phase separation in Drosophila muscle development.

The paper quantifies mechanical forces on Talin in Drosophila muscle attachment sites, showing low average forces and increased Talin concentration, suggesting only a small proportion of molecules transmit forces in vivo.

The paper identifies a biphasic mode of sarcomere development in Drosophila flight muscles, regulated by Spalt major, with distinct phases of assembly and maturation.