Maria Lynn Spletter

A mechanically regulated liquid-liquid phase separation of the transcriptional regulator Tono instructs muscle development

This study identifies Tono as a mechanically responsive transcriptional regulator that controls sarcomere maturation through liquid-liquid phase separation in Drosophila muscle development.

Bruno 1 regulates cytoskeleton dynamics and a temporal splicing transition to promote myofibril assembly, growth and maturation in Drosophila flight muscle

This study shows that Bru1 regulates cytoskeleton dynamics and a splicing transition during Drosophila flight muscle development, leading to structural defects when disrupted.

Rbfox1 is required for myofibril development and maintaining fiber-type specific isoform expression in Drosophila muscles

This study shows Rbfox1 is essential for muscle fiber development and isoform expression in Drosophila, affecting both transcript levels and splicing through multiple regulatory mechanisms.

Systematic transcriptomics reveals a biphasic mode of sarcomere morphogenesis in flight muscles regulated by Spalt

The paper identifies a biphasic mode of sarcomere development in Drosophila flight muscles, regulated by Spalt major, with distinct phases of assembly and maturation.