Frank Schnorrer

Cell type specific allometry controls sex-differences in Drosophila body size

The paper identifies sex-specific allometric strategies in Drosophila organs, showing how cell size and number differ between sexes to drive body size differences.

Microtubules coordinate mitochondria transport with myofibril morphogenesis during muscle development

This study shows microtubules coordinate mitochondria transport and myofibril formation during muscle development in Drosophila and mammals.

Muscle growth by sarcomere divisions

The paper discovers that sarcomeres divide along the myofibril tension axis during Drosophila muscle development to add new sarcomeres while maintaining mechanical integrity.

Genetically encoded reporters of actin filament organization in living cells and tissues

This paper develops genetically encoded fluorescent reporters to quantify actin filament organization in living cells and tissues using fluorescence polarization microscopy.

Spatial transcriptomics in the adult Drosophila brain and body

The paper applies spatial transcriptomics to the adult Drosophila brain and body to map mRNA locations and integrate with single-cell data.

Titin-dependent biomechanical feedback tailors sarcomeres to specialised muscle functions in insects

The paper identifies a titin-dependent biomechanical feedback mechanism that adjusts sarcomere structure to meet the functional demands of different insect muscle types.

A mechanically regulated liquid-liquid phase separation of the transcriptional regulator Tono instructs muscle development

This study identifies Tono as a mechanically responsive transcriptional regulator that controls sarcomere maturation through liquid-liquid phase separation in Drosophila muscle development.

A nanobody toolbox to investigate localisation and dynamics of Drosophila titins

The paper develops a nanobody toolbox to study the localization and dynamics of Drosophila titin homologs in muscle sarcomeres, revealing structural insights and demonstrating nanobodies' utility in vivo.

Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nano-architecture in flight muscles

The paper uses nanobodies and DNA-PAINT to show that Drosophila titin homologs Sallimus and Projectin are staggered in flight muscle sarcomeres.

Tension-driven multi-scale self-organisation in human iPSC-derived muscle fibers

This study shows that mechanical tension drives multi-scale self-organisation in human iPSC-derived muscle fibers by coordinating sarcomere assembly and myofiber bundling.

Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

AnnoMiner: a new web-tool to integrate epigenetics, transcription factor occupancy, and transcriptomics data to predict transcriptional regulators

AnnoMiner integrates epigenetic, transcription factor, and transcriptomics data to predict transcriptional regulators without requiring chromatin data from the same process.

Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle

The paper shows that myofibril and mitochondria morphogenesis in Drosophila muscles are coordinated by a biomechanical feedback mechanism involving spalt and mitochondrial dynamics.

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

This study identifies the Hippo pathway's role in regulating sarcomeric gene expression to control myofibril assembly and muscle fiber growth in Drosophila.

The Drosophila FUS ortholog cabeza promotes adult founder myoblast selection by Xrp1-dependent regulation of FGF signaling

This study shows that the Drosophila FUS ortholog cabeza regulates founder myoblast selection via Xrp1-dependent FGF signaling, affecting muscle development.

A small proportion of Talin molecules transmit forces to achieve muscle attachment in vivo

The paper quantifies mechanical forces on Talin in Drosophila muscle attachment sites, showing low average forces and increased Talin concentration, suggesting only a small proportion of molecules transmit forces in vivo.

Systematic transcriptomics reveals a biphasic mode of sarcomere morphogenesis in flight muscles regulated by Spalt

The paper identifies a biphasic mode of sarcomere development in Drosophila flight muscles, regulated by Spalt major, with distinct phases of assembly and maturation.

CHRAC/ACF Contribute to the Repressive Ground State of Chromatin

This study shows that ACF1-containing chromatin remodeling complexes repress gene expression by maintaining a repressive chromatin state in Drosophila.

A genome-wide resource for the analysis of protein localisation in Drosophila

This paper presents a genome-wide fosmid library of GFP-tagged Drosophila genes to study protein expression and localisation across developmental stages.

A versatile two-step CRISPR- and RMCE-based strategy for efficient genome engineering in Drosophila

This paper introduces a two-step CRISPR-RMCE strategy for efficient genome engineering in Drosophila, demonstrating high efficiency in modifying four different loci.