Author

Olga Perišić

MRC Laboratory of Molecular BiologyORCID 0000-0002-3842-2896Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Roger Lee WilliamsiD· 2 shared Almudena Serrano-BeníteziD· 1 shared Bilal AhsaniD· 1 shared Dénes Buzafalvi· 1 shared Iain M. HayiD· 1 shared Madhanagopal AnandapadamanabaniD· 1 shared Maxime BourguetiD· 1 shared Md Saiful IslamiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Roger Lee WilliamsORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 15, 2026

Insights into mechanisms of ATM activation via constitutively active mutants

Md Saiful Islam, Verena G. Gautsch, Rimma Belotserkovskaya…·Roger Lee Williams

This study identifies PRD mutants of ATM that are constitutively active, showing increased phosphorylation of targets without requiring MRN/DNA, and suggests potential for small-molecule modulators.

DOI 10.64898/2026.07.15.738190

humanexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintJan 8, 2026

Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop

Iain M. Hay, Maxime Bourguet, Bilal Ahsan…·Roger L. Williams

This study reveals the structural basis of a phosphoinositide-driven mTORC2-AKT positive feedback loop through cryo-EM structures and functional analysis.

DOI 10.64898/2026.01.08.698367

cryo-EMexperimental assay

𝕏 PostBluesky