Author

Madhanagopal Anandapadamanaban

MRC Laboratory of Molecular BiologyORCID 0000-0002-4237-0048Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aiwei ZengiD· 1 shared Alejandra GoityiD· 1 shared Alessandra StangherliniD· 1 shared Andrei MihutiD· 1 shared Andrew D. BealeiD· 1 shared Antony N. DoddiD· 1 shared Aymen al-RawiiD· 1 shared Bilal AhsaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCell Biology

Aiwei ZengORCID

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2 papers

Recent·Most cited

mTOR signalling, not clock gene rhythms, organises daily physiology

Aiwei Zeng, Andrei Mihut, Madhanagopal Anandapadamanaban, Alejandra Goity, Luíza Lane de Barros Dantas, Sew Y. Peak Chew, Edward A. Hayter, Linda C. Andersson, Tom S. Smith, Giacomo Pasquini, Estere Seinkmane, Alessandra Stangherlin, Nathan R. James, Charley Beresford, Jasmine Farnsworth, , John Stuart O'Neill

This study shows that mTOR signalling, not clock gene rhythms, drives daily physiological variations in mammals and plants.

bioRxiv · Oct 30, 2026 · PreprintCell Biology

Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop

Iain M. Hay, Maxime Bourguet, Bilal Ahsan, Olga Perišić, Madhanagopal Anandapadamanaban, Roger L. Williams

This study reveals the structural basis of a phosphoinositide-driven mTORC2-AKT positive feedback loop through cryo-EM structures and functional analysis.

bioRxiv · Jan 8, 2026 · PreprintBiochemistry