Author

Iain M. Hay

Babraham InstituteORCID 0000-0002-5451-1768Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Bilal AhsaniD· 1 shared Hayley J. SharpeiD· 1 shared Janet Elwyn DeaneiD· 1 shared Katie E. MulhollandiD· 1 shared Madhanagopal AnandapadamanabaniD· 1 shared Maxime BourguetiD· 1 shared Olga PerišićiD· 1 shared Roger L. WilliamsiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Bilal AhsanORCID

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2 papers

Recent·Most cited

Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop

Iain M. Hay, Maxime Bourguet, Bilal Ahsan, Olga Perišić, Madhanagopal Anandapadamanaban, Roger L. Williams

This study reveals the structural basis of a phosphoinositide-driven mTORC2-AKT positive feedback loop through cryo-EM structures and functional analysis.

bioRxiv · Jan 8, 2026 · PreprintBiochemistry

Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain

Iain M. Hay, Katie E. Mulholland, Tiffany Lai, Stephen C. Graham, Hayley J. Sharpe, Janet Elwyn Deane

The paper identifies how Afadin is recruited to PTPRK via its pseudophosphatase domain, revealing that substrate specificity is determined by interactions outside the active site.

eLife · Oct 20, 2022Peer-reviewedMolecular Biology