Sebastiaan M. Bol

This study uses single-cell RNA sequencing to map the transcriptional changes during the transition from schizont to merozoite to ring-stage Plasmodium falciparum parasites, revealing gene expression patterns related to egress, invasion, and intracellular survival.

This study investigates B cell and antibody responses to PfARMA, finding that IgM and IgG predominantly target the N-terminal IDR1 region, but these responses do not correlate with protection against malaria.

The paper identifies two human monoclonal antibodies that broadly inhibit PfEMP1's binding to EPCR, a key process in severe malaria pathogenesis.