Michelle M. Lissner

This paper designs a dynamically regulated IL-2 variant that enhances tumor-specific immune responses while reducing systemic toxicity.

This study shows that loss of FLII impairs CD8+ and regulatory T cell function by affecting trafficking and immune regulation.

The paper identifies causal genetic variants in autoimmune diseases by combining allele-specific reporter assays with chromatin accessibility data, showing their impact on gene expression and T cell function.