Joel H. Rothman

Evidence that local viscosity and NOX-dependent ROS increases render the tardigrade H. exemplaris resilient to extreme physical force

This study shows that tardigrades resist extreme hypergravity through increased intracellular viscosity and NOX-dependent ROS production.

Single-animal, single-tube RNA extraction for comparison of relative transcript levels via qRT-PCR in the tardigrade Hypsibius exemplaris.

This paper introduces a single-tardigrade RNA extraction method for qRT-PCR to compare transcript levels in Hypsibius exemplaris.

Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

This study shows that programmed cell death and aging pathways regulate mtDNA quality control and transmission in C. elegans by affecting the accumulation of a defective mtDNA mutation.

Mechanosensory Systems and Sensory Integration Mediate C. elegans Negative Gravitaxis

This study identifies ion channels and neurons essential for gravity sensing in C. elegans, showing distinct mechanisms from touch sensation and suggesting evolutionary homology with mammalian systems.

An Autonomous Molecular Bioluminescent Reporter (AMBER) for voltage imaging in freely moving animals

The paper introduces AMBER, a genetically encoded bioluminescent voltage indicator that does not require exogenous substrate, enabling voltage imaging in freely moving animals.

Feedforward regulatory logic underlies robustness of the specification-to-differentiation transition and fidelity of terminal cell fate during C. elegans endoderm development

The paper identifies a feedforward regulatory logic in C. elegans endoderm development that ensures robustness and fidelity of cell fate specification and differentiation.

Early C. elegans embryos modulate cell division timing to compensate for, and survive, the discordant conditions of a severe temperature gradient

The paper shows C. elegans embryos adjust cell division timing in response to temperature gradients to maintain developmental fidelity.

Natural cryptic variation in epigenetic modulation of an embryonic gene regulatory network

The paper investigates how heritable epigenetic factors contribute to cryptic variation in the requirement for SKN-1 in endoderm development in C. elegans.

Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death

This study shows that separase and caspases, though specialized in cell division and apoptosis, can partially substitute for each other in C. elegans, suggesting evolutionary co-option of cellular components.

Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network

The paper identifies cryptic variation in the C. elegans endoderm gene regulatory network, showing that some embryos can develop endoderm without key regulators, while others require them.