Author
University of BristolORCID 0000-0002-3874-0683Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Yi Liu, Benjamin Elsworth, Pau Erola, Valeriia Haberland, Gibran Hemani, Matthew Lyon, Jie Zheng, Oliver C Lloyd, Marina Vabistsevits, Tom R. Gaunt
EpiGraphDB is a graph database and analytical platform for health data science, demonstrating its utility through case studies on pleiotropy, drug targets, and causal inference.
Bioinformatics · Nov 4, 2020Peer-reviewedBioinformatics
Jie Zheng, Valeriia Haberland, Denis A. Baird, Venexia M. Walker, Philip Haycock, Mark R. Hurle, Alex Gutteridge, Pau Erola, Yi Liu, Shan Luo, Jamie W. Robinson, Tom G. Richardson, James R Staley, Benjamin Elsworth, Stephen Burgess, , Tom R. Gaunt
This paper uses Mendelian randomization and colocalization to identify causal relationships between plasma proteins and disease phenotypes, finding 111 putatively causal effects.
Nature Genetics · Sep 7, 2020Peer-reviewedGenetics
Benjamin Elsworth, Matthew Lyon, Tessa Alexander, Yi Liu, Peter Matthews, Jon Hallett, Phil Bates, Tom Palmer, Valeriia Haberland, George Davey Smith, Jie Zheng, Philip Haycock, Tom R. Gaunt, Gibran Hemani
OpenGWAS serves 14582 harmonised, complete GWAS summary datasets (125.8 billion associations) via API, R/Python clients and GWAS-VCF downloads, with glue code for Mendelian randomization, colocalisation and fine-mapping.
bioRxiv · Aug 10, 2020 · PreprintGenetics✦ In-depth digest
Ioanna Tachmazidou, Konstantinos Hatzikotoulas, Lorraine Southam, Jorge Esparza-Gordillo, Valeriia Haberland, Jie Zheng, Toby Johnson, Mine Koprulu, Eleni Zengini, Julia Steinberg, Jeremy Mark Wilkinson, Sahir Bhatnagar, Joshua Hoffman, Natalie S. Buchan, Dániel Süveges, , Eleftheria Zeggini
This study identifies 64 new genetic signals for osteoarthritis using UK Biobank data, including 52 novel loci, and highlights potential therapeutic targets with existing drugs.
Nature Genetics · Jan 21, 2019Peer-reviewedGenetics