Author

Eleni Zengini

University of Sheffield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 4 Assay:GWAS summary statistics· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:fine-mapping· 1

Frequent Co-Authors

Eleftheria ZegginiiD· 4 shared Jeremy Mark WilkinsoniD· 4 shared Julia SteinbergiD· 4 shared Konstantinos HatzikotoulasiD· 4 shared George Davey SmithiD· 3 shared Lorraine SouthamiD· 3 shared André Gerardus UitterlindeniD· 2 shared Arthur GillyiD· 2 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Eleftheria ZegginiORCID

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4 papers

Recent·Most cited

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

April E. Hartley, Eleanor C. M. Sanderson, Raquel Granell, Lavinia Paternoster, Jie Zheng, George Davey Smith, Lorraine Southam, Konstantinos Hatzikotoulas, Cindy Germaine Boer, Joyce B. J. van Meurs, Eleftheria Zeggini, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida, Tian T. Wu, , Jonathan H. Tobias

This study uses multivariable Mendelian randomization to show that higher bone mineral density causally increases osteoarthritis risk independently of body mass index.

International Journal of Epidemiology · Nov 15, 2021Peer-reviewedGenetic & Genomic Medicine

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank

Ioanna Tachmazidou, Konstantinos Hatzikotoulas, Lorraine Southam, Jorge Esparza-Gordillo, Valeriia Haberland, Jie Zheng, Toby Johnson, Mine Koprulu, Eleni Zengini, Julia Steinberg, Jeremy Mark Wilkinson, Sahir Bhatnagar, Joshua Hoffman, Natalie S. Buchan, Dániel Süveges, , Eleftheria Zeggini

This study identifies 64 new genetic signals for osteoarthritis using UK Biobank data, including 52 novel loci, and highlights potential therapeutic targets with existing drugs.

Nature Genetics · Jan 21, 2019Peer-reviewedGenetics

The genetic architecture of osteoarthritis: insights from UK Biobank

Eleni Zengini, Konstantinos Hatzikotoulas, Ioanna Tachmazidou, Julia Steinberg, Fernando Pires Hartwig, Lorraine Southam, Sophie Hackinger, Cindy Germaine Boer, Unnur Styrkársdóttir, Arthur Gilly, Dániel Süveges, Britt Kilian, Þorvaldur Ingvarsson, Helgi Jónsson, George C. Babis, , Eleftheria Zeggini

This study identifies 9 new osteoarthritis loci using UK Biobank data and finds causal effects of higher body mass index on osteoarthritis.

Nature Genetics · Mar 20, 2018Peer-reviewedGenetics

The Genetic Epidemiology of Developmental Dysplasia of the Hip: A Genome-Wide Association Study Harnessing National Clinical Audit Data

Konstantinos Hatzikotoulas, Andreas Roposch, Karan Mehul Shah, Matthew J. R. Clark, Selina Bratherton, Vasanti Limbani, Julia Steinberg, Eleni Zengini, Kaltuun Warsame, Madhushika Ratnayake, Maria Tselepi, Jeremy Schwartzentruber, John A. Loughlin, Deborah M. Eastwood, Eleftheria Zeggini, Jeremy Mark Wilkinson

This paper conducts a genome-wide association study on developmental dysplasia of the hip using national clinical audit data, identifying genetic loci associated with the condition and demonstrating a scalable recruitment strategy.

bioRxiv · Jun 24, 2017 · PreprintGenetics