Ashok Kumar

Identification and functional characterization of LDB3 gene variants in DCM patients from Indian Population

This study identifies and functionally characterizes LDB3 gene variants in Indian DCM patients, finding six novel missense variants that affect protein structure, expression, and Z-disc integrity.

Implication of novel variants of BMP2 in isolated congenital heart disease: Functional characterization by in silico and invitro approaches

The paper identifies and functionally characterizes BMP2 variants in congenital heart disease using in vitro and in silico methods, showing increased pathway activity.

Functionally significant, novel variants of BMP4 are associated with isolated congenital heart disease

The paper identifies four novel BMP4 variants associated with congenital heart disease and shows they enhance BMP signaling through increased SMAD phosphorylation and downstream gene expression.

Drug screen reveals new potent host-targeted antivirals against Mpox virus

The paper identifies potent host-targeted antivirals against Mpox virus through high-throughput screening of a kinase inhibitor library, showing efficacy in vitro and in a mouse model.