Vaithilingaraja Arumugaswami

This study integrates multi-omics data to compare endothelial cell responses to New and Old World hantaviruses, identifying species-specific immune and cellular mechanisms.

This study shows the SARS-CoV-2 nucleocapsid protein drives hyperinflammation and vascular leakage in macrophages via Toll-like receptor signaling, contributing to severe COVID-19 complications.

The paper identifies potent host-targeted antivirals against Mpox virus through high-throughput screening of a kinase inhibitor library, showing efficacy in vitro and in a mouse model.

This study uses a primary human stem cell-based airway model to screen 2100 compounds and identifies a small molecule effective against SARS-CoV-2 and its Omicron variant.

This paper designs structure-based antisense oligonucleotides (ASOs) that inhibit SARS-CoV-2 replication by targeting RNA structures rather than just sequences.

This study investigates the pathogenesis of Zika virus infection via the rectal route and its potential implications for transmission and disease outcomes.

This study models ZIKV-induced congenital eye disease by comparing susceptibility of fetal retinal cells and iPSC-derived retinal stem cells, identifying molecular pathways and potential therapeutic targets.

This study identifies differentially expressed lncRNAs and their interactions during ZIKV infection, revealing potential roles in cell division and fetal development.

The paper identifies C19ORF66 as an IFN-stimulated gene that inhibits HIV-1 by blocking virion production.

This study compares protein evolution and RNA structural changes in pre-epidemic and epidemic Zika virus strains to identify adaptation mechanisms to the human host.