Qing Zhou

Pathway-enhanced Transformer-based robust model for quantifying cell types of origin of cell-free transcriptome

Deconformer improves cell type deconvolution of cell-free RNA by integrating biological pathways, showing better performance and interpretability across multiple datasets.

Impact of blood storage conditions on the transcript profile of plasma cell-free RNA

This study evaluates how blood storage conditions affect plasma cell-free RNA transcript profiles, finding that mRNA and lncRNA stability is highest at 4°C for 6 hours or RT for 2 hours.

CNV-PG: a machine-learning framework for accurate copy number variation predicting and genotyping

CNV-PG is a machine-learning framework that improves CNV prediction and genotyping accuracy by reducing false positives and integrating results from multiple callers.

PALM-Seq: simultaneous sequencing of cell-free long RNA and small RNA

PALM-Seq simultaneously sequences cell-free long and small RNA, identifying pregnancy-related RNAs and sample-specific signatures in plasma, amniotic fluid, leukocytes, and placentas.

Single-cell RNA-seq reveals distinct dynamic behavior of sex chromosomes during early human embryogenesis

The paper analyzes single-cell RNA-seq data from human embryos to compare gene expression between males and females, identifying differences in sex chromosome activation and dosage compensation during early development.