Xinyi Jenny He

The paper shows that primary cilia in striatal neurons facilitate dopamine receptor-initiated cAMP/PKA signaling beyond the cilium, challenging the view that ciliary neurotransmission is restricted to non-canonical pathways.

The paper shows that GPCRs can distinguish neuromodulatory inputs through temporal coding, despite sharing a common transducer pathway.

This paper introduces photoactivatable opioid drugs for in vivo photopharmacology, enabling rapid, localized manipulation of opioid receptors and associated behaviors.

The paper shows that mu and delta opioid receptors in hippocampal parvalbumin interneurons signal independently despite convergent and redundant pathways.

The paper develops a caged mu opioid receptor agonist that, when photoactivated, rapidly increases locomotion in mice.