Cancer BiologyCancer Immunology ImmunotherapyPeer-reviewed
Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer
Nilesh Deshpande, Anna Bianchi, Haleh Amirian…·Jashodeep Datta
The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.
10 citations