Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer
Nilesh Deshpande, Anna Bianchi, Haleh Amirian, Iago De Castro Silva, Christine Isabelle Rafie, Bapurao Surnar, Karthik Rajkumar, Ifeanyichukwu Chinedu Ogobuiro, Manan Patel, Siddharth Mehra, Nagaraj S. Nagathihalli, Nipun B. Merchant, Shanta Dhar, Jashodeep Datta
The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.
Cancer Immunology Immunotherapy · Jun 23, 2025Peer-reviewedCancer Biology