Brendan L. O’Connell

This study maps early postnatal DNA methylation dynamics in the mouse brain, revealing subtype-specific methylation changes and their disruption in Rett syndrome.

This study functionally characterizes mutant ASXL1 in human hematopoietic stem cells, showing it drives transcriptional activation and repression through interactions with BRD4 and MECOM, with implications for therapy.

The paper introduces sciMETv3, a high-throughput single-cell DNA methylation profiling method, achieving 100-fold higher cell throughput and compatibility with multimodal assays.

This paper reports the 3D genome architecture of a 52,000-year-old woolly mammoth using a novel method, revealing conserved epigenetic features across elephantids.

sciMET-cap reduces sequencing burden for single-cell methylation analysis while enabling accurate cell type assignment and near-complete methylome reconstruction.

The paper introduces Cas12a-Capture, a low-cost, scalable targeted sequencing method that reduces GC bias and improves variant calling accuracy.

This paper introduces a novel adaptor-switching strategy, s3, that significantly improves usable reads per cell in single-cell genomics assays while maintaining high-throughput capabilities.

The paper shows that inducing DNA breaks accelerates aging-related chromatin changes and loss of cell identity in mammals.

This study examines how chromosomal rearrangements in the gibbon genome affect TAD boundaries and epigenetic features, finding overlap between rearrangement breakpoints and TAD boundaries.

The paper presents an updated horse reference genome, EquCab3, which improves contiguity and composition compared to the previous version, EquCab2.

The paper analyzes genomic data from passenger pigeons and their relatives to show that natural selection reduced neutral genetic diversity despite large population size, challenging previous extinction theories.