Augustine C. Onyema

This paper uses molecular dynamics simulations and a new Python library to map allosteric communication in the nucleosome, identifying kinetically connected domains and dynamic coupling over long distances.

This study examines how two oncogenic histone mutations affect nucleosome stability through molecular dynamics simulations and biophysical assays, showing reduced interface stability and altered thermal properties.

This study compares all-atom and coarse-grained simulations of nucleosome dynamics using the SIRAH force field, revealing similar structural parameters but distinct conformational sampling and breathing motion in coarse-grained models.