Rutika Patel

The paper shows DNA sequence and H2A.Z histone variant jointly determine nucleosome unwrapping directionality through simulations and NMR data.

This study investigates how H2A.Z affects Sox2 and Oct4 binding to nucleosomes by altering DNA and histone H3 tail dynamics.

This paper uses molecular dynamics simulations and a new Python library to map allosteric communication in the nucleosome, identifying kinetically connected domains and dynamic coupling over long distances.

This study examines how two oncogenic histone mutations affect nucleosome stability through molecular dynamics simulations and biophysical assays, showing reduced interface stability and altered thermal properties.

This study uses molecular dynamics simulations and Markov state models to analyze histone tail conformations and shows acetylation increases H2B tail dynamics.

This study compares all-atom and coarse-grained simulations of nucleosome dynamics using the SIRAH force field, revealing similar structural parameters but distinct conformational sampling and breathing motion in coarse-grained models.