Sharon M. Loverde

DNA Sequence and Histone Variant H2A.Z Jointly Govern Nucleosome Unwrapping Pathways

The paper shows DNA sequence and H2A.Z histone variant jointly determine nucleosome unwrapping directionality through simulations and NMR data.

H2A.Z facilitates Sox2-nucleosome interaction by promoting DNA and histone H3 tail mobility

This study investigates how H2A.Z affects Sox2 and Oct4 binding to nucleosomes by altering DNA and histone H3 tail dynamics.

Mapping Allosteric Communication in the Nucleosome with Conditional Activity

This paper uses molecular dynamics simulations and a new Python library to map allosteric communication in the nucleosome, identifying kinetically connected domains and dynamic coupling over long distances.

Structural and Thermodynamic Impact of Oncogenic Mutations on the Nucleosome Core Particle

This study examines how two oncogenic histone mutations affect nucleosome stability through molecular dynamics simulations and biophysical assays, showing reduced interface stability and altered thermal properties.

Unveiling the Conformational Dynamics of the Histone Tails Using Markov State Modeling

This study uses molecular dynamics simulations and Markov state models to analyze histone tail conformations and shows acetylation increases H2B tail dynamics.

Unveiling Nucleosome Dynamics: A Comparative Study Using All-Atom and Coarse-Grained Simulations Enhanced by Principal Component Analysis

This study compares all-atom and coarse-grained simulations of nucleosome dynamics using the SIRAH force field, revealing similar structural parameters but distinct conformational sampling and breathing motion in coarse-grained models.